Illinois Route 92 is an east–west state highway in northwest Illinois. It runs from Iowa Highway 92 at the Norbert F. Beckey Bridge across the Mississippi River to Muscatine, Iowa east to U.S. Route 34 in La Moille. This is a distance of 106.41 miles (171.25 km).

Illinois 92 carries the Centennial Expressway through Rock Island. It also forms a continuous "Route 92" through the states of Iowa, Nebraska and Wyoming, but besides Omaha, Nebraska, the combined state routes do not pass through any major cities.