State Route 93 is a north–south highway that stretches from Ironton at U.S. Route 52 to State Route 261 in Akron. The route from Ironton to West Lafayette was once signed as State Route 75. In 1962, to eliminate confusion with an interstate in Ohio having the same number, State Route 75 was replaced by State Route 93 which had previously terminated in West Lafayette.

State Route 93 begins at an interchange in Ironton and heads north. Within a few miles, the route goes through Wayne National Forest and Lake Vesuvius. After leaving Wayne National Forest, the route enters Jackson County and the town of Oak Hill where it intersects with Ohio 140 and Ohio 279. The route passes through less hilly areas as it once did in Lawrence County. The route passes through Jackson, and in the village of Coalton, State Route 93 makes a sharp turn eastward to Wellston, where it overlaps State Route 327. After Wellston, State Route 93 returns on its northerly route to Hamden, McArthur, Logan, New Lexington, Crooksville, and Zanesville. Between Zanesville and Ironton, State Route 93 is a busy truck route and used by many travelers as well. Leaving Zanesville, the route is less traveled heading north to Canal Fulton. From there, it gradually becomes more and more traveled, until it reaches the Portage Lakes region. At this point, it is a road in which traffic jams are expected during rush hour. It is the same entering Akron.

At the interchange with U.S. Route 52 and State Route 93 in Ironton, there is a small tunnel in which State Route 75 (before it was State Route 93) used to pass through until the road was widened. A hill was cut just to the left of the tunnel. The tunnel is now closed and is a small historical attraction to remind people of Historical Route 75 with a small sign of State Route 75.