Pennsylvania Route 424 (PA 424) is a 4 mile long state highway located in north-central Pennsylvania. The western terminus is at Interstate 81 exit 141 in Hazle Township. The eastern terminus is at Pennsylvania Route 93 on the southeastern edge of Hazleton. The highway is called The Greater Hazleton Chamber Of Commerce Beltway.

PA 424 begins at I-81 exit 141 in Hazle Township. The route heads east as a two-lane undivided road called The Greater Hazleton Chamber Of Commerce Beltway, passing through forested areas. The road turns northeast and comes to an intersection with PA 309, briefly becoming a divided highway at this point. East of PA 309, PA 424 crosses a Norfolk Southern railroad line and heads into the southern part of Hazleton. The route passes through more woodland along with a few industrial establishments, running to the north of a coal mine. PA 424 continues east and enters Hazle Township again, immediately ending at PA 93.

PA 424 is composed of two different road segments. The first was built in the 1970s between PA 93 and PA 309 and had the designation of SR 3036. The rest of the road to Interstate 81 was built in the late 1990s and opened to traffic in late 1999. In spring 2000 the first 424 shields started to appear on the road. Plans exist for the road to go west to Pennsylvania Route 924 in the Humboldt Industrial Park however lack of funds has put the project on hold.

The entire route is in Luzerne County.