South Carolina Highway 48 (SC 48) is a primary state highway in the U.S. state of South Carolina. It serves southern Richland County and access to the Congaree National Park.

SC 48 begins in downtown Columbia, along Assembly Street. It traverses west, passing alongside the South Carolina State House and the University of South Carolina, before turning onto Rosewood Drive and then onto Bluff Road. After leaving the Columbia city limits, it continues through southeastern Richland County as a two-lane rural highway to US 601.

Established in 1930 as a new primary routing, it originally traversed from Gervais Street, going east along Assembly Street, to US 601 in Wateree. Various adjustments in its downtown routing have been made between 1937-46. In 1950, SC 48 was straightened out between Gadsden and Wateree, leaving behind Old Bluff Road. In 1978, SC 48 was extended west to its current western terminus at Elmwood Avenue.

The entire route is in Richland County.