State Highway 255 (SH 255) toll road owned by the state of Texas that has operated since 2000 that allows international traffic to bypass Laredo. The route stretches from the Colombia Solidarity International Bridge to Interstate 35 at exit #24. It is one of the few operating toll roads in the United States to have gone through the legal process of foreclosure.

SH 255 begins at the Colombia Solidarity International Bridge on the United States-Mexico border northwest of Laredo in Webb County. It heads northeast from the border as a 4-lane divided highway to an intersection with FM 1472. The highway continues to the northeast as a 4-lane divided highway but merges down to a 2-lane road just west of the former toll barrier. SH 255 continues northeast to an intersection at FM 3338 and a diamond interchange with US 83. It continues to the northeast to its eastern terminus at I-35.

Since June 1, 2009, use of the TxTag electronic toll collection system (or the interoperable EZ TAG and TollTag system) has been mandatory; unlike other TxDOT-operated toll roads, there is no pay-by-mail option. Laredo Trade Tags may also be used if they are tied to a TxTag account.

The route was originally approved in 1997 as a privately owned toll route for mainly truck traffic to bypass the city of Laredo for traffic congestion. The route was opened as the Camino Colombia Toll Road in October 2000, costing around $90 million.

In August 2001, landowners that were shareholders of the route filed a lawsuit, claiming that profits and traffic usage were less than expected. The failure of the route was attributed to the price for truck traffic ($16), the continuation of U.S. government policies banning Mexican trucks from the interior of the United States (which had been expected to be abolished under the North American Free Trade Agreement), and the approval of a new freeway connecting route from the World Trade International Bridge crossing along Loop 20 to Interstate 35.

The toll road was foreclosed on late in 2003, and was auctioned off on the steps of the Webb County courthouse January 6, 2004. It was purchased by its main creditor, the John Hancock Life Insurance Company, for the minimum $12 million, 1/6 of the construction value. The only other bidder was the Texas Department of Transportation at $11 million. The route was subsequently closed to all traffic. In May 2004, TxDOT purchased the route from John Hancock for a negotiated $20 million, and reopened the route in September, dropping the toll to $2 toll for cars and $2 per additional axle.

SH 255 inherited its number from FM 255, which was designated on the route between the border crossing and FM 1472 in 1989. The SH 255 designation was extended over this segment in 2005.

A previous route existed with the SH 255 designation, beginning in Bremond and traveling southeast to Bryan. This route became FM 46 by 1942.