Beginning at a junction with Business Loop I-20 at Big Spring in Howard County, SH 350 intersects Interstate 20 on the northern edge of the town. The highway is known as Owen Street in Big Spring. SH 350 then runs northeast past Howard County municipal airport to its final junction with US 180 at Snyder in Scurry County, where it is known as College Avenue. The route traverses Howard, Mitchell and Scurry counties. Except for the portions in Big Spring and Snyder, most of the terrain covered by the highway is lightly populated agricultural and oil country. The route has remained essentially unchanged since its original designation in 1943.