U.S. Route 19 in West Virginia runs 249 miles (401 km) through West Virginia from the Virginia state line in Bluefield, WV to the Pennsylvania state line near Mount Morris, PA.

US 19 enters West Virginia as a six lane highway near Bluefield, where it narrows to a two-lane as it winds northward. It later parallels Interstate 77 and 64 until it reaches Beckley, where it becomes the four-lane Corridor L. It crosses the New River Gorge Bridge at Fayetteville and passes through Summersville, and Birch River before arriving at Interstate 79, five miles (8 km) south of Sutton. From there, it runs concurrent with Interstate 79 from exit 57 to exit 67 at Flatwoods, West Virginia . Then, it exits and reverts a two lane highway, more or less following the route of I-79 as it passes through Weston, Clarksburg, Fairmont, and Morgantown before crossing into Pennsylvania.

Route 19 through Summersville, West Virginia has been dubbed the "World's Largest Speed Trap."