I-516 spurs off in two opposite directions, perpendicular to I-16.
I-16 serves as a hurricane evacuation route for Savannah and other coastal areas. The road is designed for contraflow travel with railroad-type gates to most block entrance and exit ramps for the normally eastbound lanes. Some ramps are ungated, apparently for entrance to and exit from the contraflow lanes. Just east of Exit 42 is a crossover to return all westbound traffic to the westbound travel lanes.
Southeast of Macon, I-16 passes through Ocmulgee National Monument but without direct access. Visitors need to first exit at the Colliseum Drive (U.S. Route 80) exit.