Interstate 40 (abbreviated I-40) is a major west-east interstate highway in the United States. Its western terminus is at Interstate 15 in Barstow, California; its eastern terminus is at a concurrency of U.S. Route 117 and North Carolina Highway 132 in Wilmington, North Carolina. Much of the western portion of I-40, from Oklahoma City to Barstow, parallels historic U.S. Route 66. I-40 connects to 8 of the 10 primary north-south interstates (all except I-5 and I-45).

When the last portion of I-40, connecting Wilmington to Raleigh, was completed in the late 1980s, Charles Kuralt stated:

"Thanks to the interstate highway system, it is now possible to travel from coast to coast without seeing anything."

I-40 map