In the state of Missouri, Interstate 57 runs from Miner to the Cairo I-57 Bridge over the Mississippi River south of Cairo, Illinois.
After ending at Interstate 55, the highway continues as U.S. Highway 60, which meets U.S. Highway 67 at Poplar Bluff, Missouri and from here US 67 goes south to Little Rock, Arkansas. The state of Missouri has proposed extending the I-57 designation down this corridor. However, this plan conflicts with Arkansas' plans to extend the Interstate 30 designation north on US 67, a road of which a long section already meets Interstate highway standards.
In the state of Illinois, Interstate 57 runs from the bridge over the Mississippi River north to Chicago. I-57 is the longest Interstate highway in Illinois. The route is an easy way to reach Shawnee National Forest in the southern tip of the state. It also serves as a major artery for college students in the state, running near Southern Illinois University in Carbondale, Eastern Illinois University in Charleston, Parkland College in Champaign, University of Illinois at Urbana-Champaign in Urbana-Champaign, Kankakee Community College in Kankakee, Olivet Nazarene University in Bourbonnais, and Governors State University in University Park.
I-57 is currently the only Chicago-area expressway that does not have a common name, although the state of Illinois has designated it the Thurgood Marshall Memorial Freeway.