Interstate 69 currently exists in two distinct sections: a continuous route from Indianapolis, Indiana to the Blue Water Bridge at Port Huron, Michigan, and a relatively short spur from Tunica Resorts to Hernando, Mississippi.
Currently, Interstate 69 in Indiana starts at an interchange with Interstate 465 in northeastern Indianapolis, running roughly northeast to near Anderson, Indiana, where it turns more easterly to provide indirect access to Muncie before turning more northerly towards Fort Wayne. In Fort Wayne, I-69 roughly runs along the western edge of the city while an auxiliary route, Interstate 469, loops east of the city. I-69 continues northerly to the Indiana Toll Road near Fremont, then crosses the border into Michigan just south of Kinderhook.
I-69 in Michigan runs north passing through Coldwater and Marshall. Near Olive, I-69 begins to turn in a northeasterly direction passing through the Lansing metropolitan area. Here I-69 is cosigned on with I-96, the only such palendromic pairing in the entire Interstate Highway System. I-69 is signed east-west from Lansing through Flint to Port Huron. At the eastern terminus, I-69 joins I-94 to cross the Blue Water Bridges at the Canadian border over the St. Clair River.