State Route 150 (SR 150) is a highway that runs northeast-to-southwest through portions of Columbia and McDuffie counties in eastern Georgia. The route runs from its northeastern terminus at the South Carolina state line west of Clarks Hill to its southwestern terminus at US 78, SR 10 and SR 17 in Thomson.

The route is co-signed for 5.6 miles (9.0 km) with US 221 from the South Carolina state line to its junction with SR 47, then continues southwest for 19.6 miles (31.5 km) as just SR 150 from this intersection. It crosses I-20 northeast of Thomson and its southern terminus.