State Route 111 is a north–south highway in Middle and East Tennessee. The road begins in Soddy-Daisy and ends north of Byrdstown in the community of Static, at the Tennessee/Kentucky state line. The length is 118.72 mi (191.1 km).

The highway begins at an intersection with U.S. Highway 27/SR-29 in Soddy-Daisy. SR-111 travels generally northeast before it crosses into Sequatchie County. It then proceeds over Walden Ridge and into the Sequatchie Valley, where it starts a concurrency with SR-8 in Dunlap. The concurrency goes up the Cumberland Plateau and into the northern part of the county where SR-8 splits off and continues to McMinnville. SR-111 turns north at this point and crosses into Van Buren County.

In Van Buren County, the highway travels through the small town of Spencer, passing just east of Fall Creek Falls State Park, and continues into White County at the Caney Fork River. The highway then proceeds north as Harold "Mose" Sims Memorial Highway and joins the concurrency of U.S. Route 70S/SR-1. The concurrency continues to the east side of Sparta, at which point the highways split up and SR-111 continues north into Putnam County.

Entering Putnam by crossing the Falling Water River, the highway passes through eastern Cookeville. Here it intersects Interstate 40 and U.S. Route 70N as it turns north-northeastward and into the town of Algood. After passing Algood, SR-111 turns northeastward and enters Overton County.

In Overton, SR-111 becomes Cookeville Highway and then Veterans Memorial Parkway as it approaches Livingston. It then becomes a bypass around the northwest of town and becomes Bradford Hicks Drive before exiting Livingston and continuing northeast as Brydstown Highway. It crosses into Pickett County and becomes Livingstorn Highway. Then, it crosses the Obey River and enters into Byrdstown.

After traversing Byrdstown, the highway continues northeastward as Robert H. Roberts Memorial Highway before ending at U.S. Highway 127/SR-28 in Static, just yards from the Tennessee-Kentucky state line. From this intersection, US-127 runs northwestward to Albany, Kentucky, and southeastward toward Jamestown, Tennessee, while KY-1076 continues northeastward, in the direction of Monticello, Kentucky.