State Highway 64 is a Texas state highway that runs from Wills Point via Tyler to Henderson. (Rusk, Smith, and Van Zandt Counties)

SH 64 was originally designated between 1922 and 1926 to replace SH 15A from Wills Point to Carthage, then continuing on to the Louisiana state line. In 1935, the portion east of Henderson was reassigned to U.S. Highway 79. The remaining portion has not changed since.