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Interstate 10 California

Between its west terminus in Santa Monica, California and the East Los Angeles Interchange it is known as the Santa Monica Freeway. The Santa Monica Freeway is also called the "Rosa Parks Freeway" for the segment beginning at the San Diego Freeway (The 405 Freeway) and ending at the Harbor Freeway (The 110 Freeway), however either name can be used when referring to this stretch of road. The segment between the East Los Angeles Interchange and the city of San Bernardino, California (53 miles, or 92 km long) is known as the San Bernardino Freeway. Other names exist for the freeway. For example, a sign near the western terminus of the highway announces it as the "Christopher Columbus Transcontinental Highway". It is known to a considerably lesser degree as the "Veterans Memorial Highway" and is listed as a Blue Star Highway.

A stretch in Palm Springs is signed as the "Sonny Bono Memorial Freeway" as a tribute to the late entertainer who served both as mayor and as a United States Congressman. A second stretch a short distance east in Indio is signed as the "Doctor June McCarroll Memorial Freeway". As a nurse with the Southern Pacific Railroad in 1924, Dr. McCarroll was alarmed at the number of head-on traffic collisions on a nearby stretch of then-new U.S. Route 99, today known as State Route 86. She is credited with painting a white stripe down the middle of 99 near Coachella in order to separate the two lanes of traffic.

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