Florence, South Carolina is close to the interstate highway I-20. It is neighboring other cities: Hickory Grove, SC (4.6mi/11m ); Glendale, SC (6.7mi/12m ); Darlington, SC (10.7mi/18m ). You can get to the city from exit 141b a of i20 (2.4mi/4m ); exit 160a of i95 (2.4mi/4m ); exit 160b of i95 (2.4mi/4m ). Florence, South Carolina can reach interstate highways: i20 (2.4mi/4m ); i95 (2.4mi/4m ); i77 (69.8mi/1.3h ). It is also close to local highways: SC 51 (0.9mi/2m ); US 52 SC (3.4mi/6m ); US 301 SC (5.2mi/9m ).