Las Cruces, New Mexico is close to the interstate highway I-25. It is neighboring other cities: Mesilla, NM (5.55 mi ); Mesilla Park, NM (10.42 mi ); Dona Ana, NM (11.09 mi ). You can get to the city from exit 3 of i25 (1.49 mi ); exit 1 of i25 (2.26 mi ); exit 142 of i10 (2.57 mi ). Las Cruces, New Mexico can reach interstate highways: i25 (1.49 mi ); i10 (2.57 mi ); i20 (289.73 mi ). It is also close to local highways: NM 478 (1.62 mi ); NM 28 (1.97 mi ); NM 188 (2.09 mi ).