Pueblo, Colorado is close to the interstate highway I-25. It is neighboring other cities: Avondale, CO (27.29 mi ); Boone, CO (29.81 mi ); Colorado Springs, CO (39.92 mi ). You can get to the city from exit 99b a of i25 (3.06 mi ); exit 98b of i25 (3.19 mi ); exit 100a of i25 (3.19 mi ). Pueblo, Colorado can reach interstate highways: i25 (3.06 mi ); i70 (130.82 mi ); i225co (153.13 mi ). It is also close to local highways: US 50 CO (0.27 mi ); CO 96 (1.25 mi ); CO 47 (1.26 mi ).