Santa Fe, New Mexico is close to the interstate highway I-25. It is neighboring other cities: Tesuque, NM (8.36 mi ); Glorieta, NM (22.67 mi ); Santa Cruz, NM (26.84 mi ). You can get to the city from exit 284 of i25 (14.28 mi ); exit 282 of i25 (14.39 mi ); exit 278 of i25 (16.41 mi ). Santa Fe, New Mexico can reach interstate highways: i25 (14.28 mi ); i40 (77.23 mi ); i27 (377.57 mi ). It is also close to local highways: US 84 NM (5.59 mi ); NM 592 (5.66 mi ); NM 599 (5.94 mi ).