Dona Ana, New Mexico is close to the interstate highway I-25. It is neighboring other cities: San Miguel, NM (3.24 mi ); Las Cruces, NM (5.02 mi ); Mesilla, NM (14.02 mi ). You can get to the city from exit 9 of i25 (0.95 mi ); exit 6 of i25 (5.69 mi ); exit 3 of i25 (10.50 mi ). Dona Ana, New Mexico can reach interstate highways: i25 (0.95 mi ); i10 (11.14 mi ); i40 (290.12 mi ). It is also close to local highways: NM 320 (0.69 mi ); NM 185 (3.78 mi ); US 70 NM (5.71 mi ).