Mesilla, New Mexico is close to the interstate highway I-25. It is neighboring other cities: Las Cruces, NM (4.53 mi ); Mesilla Park, NM (10.13 mi ); Dona Ana, NM (14.02 mi ). You can get to the city from exit 140 of i10 (2.81 mi ); exit 139 of i10 (2.93 mi ); exit 142 of i10 (4.29 mi ). Mesilla, New Mexico can reach interstate highways: i10 (2.81 mi ); i25 (6.66 mi ); i20 (292.01 mi ). It is also close to local highways: NM 359 (0.43 mi ); NM 372 (0.46 mi ); NM 373 (1.25 mi ).