Las Cruces, New Mexico is close to the interstate highway I-25. It is neighboring other cities: Mesilla Park, NM (2.6mi/6m ); Mesilla, NM (3.6mi/9m ); San Ysidro, NM (5.5mi/13m ). You can get to the city from exit 3 of i25 (1.3mi/4m ); exit 1 of i25 (2mi/5m ); exit 142 of i10 (4mi/7m ). Las Cruces, New Mexico can reach interstate highways: i25 (1.3mi/4m ); i10 (4mi/7m ); i20 (223.6mi/3.8h ). It is also close to local highways: NM 478 (1.2mi/3m ); NM 28 (1.3mi/3m ); NM 188 (2.1mi/5m ).