Santa Fe, New Mexico is close to the interstate highway I-25. It is neighboring other cities: Tesuque, NM (8.1mi/22m ); La Loma, NM (14.6mi/33m ); Arroyo Seco, NM (23.8mi/39m ). You can get to the city from exit 284 of i25 (12.3mi/27m ); exit 282 of i25 (12.6mi/28m ); exit 278 of i25 (16.1mi/30m ). Santa Fe, New Mexico can reach interstate highways: i25 (12.3mi/27m ); i40 (75.5mi/1.8h ); i27 (287.6mi/5.3h ). It is also close to local highways: US 84 NM (9.8mi/22m ); NM 592 (10.2mi/23m ); NM 599 (7.7mi/19m ).