Saint Louis, Missouri is close to the interstate highway I-270 MO. It is neighboring other cities: East Saint Louis, IL (2.9mi/5m ); Venice, IL (4.5mi/8m ); Madison, IL (5.5mi/10m ). You can get to the city from exit 250a of i70 (3.8mi/7m ); exit 250b of i70 (3.6mi/6m ); exit 249c of i70 (1.1mi/3m ). Saint Louis, Missouri can reach interstate highways: i70 (3.8mi/7m ); i64 (1.4mi/4m ); i55 (1.2mi/3m ). It is also close to local highways: US 40 MO (1.3mi/4m ); MO 100 (1.4mi/3m ); US 40 IL (2.4mi/5m ).