San Francisco, California is close to the interstate highway I-5. It is neighboring other cities: Forest Knolls, CA (3.3mi/9m ); Portola, CA (4.1mi/8m ); Lakeside, CA (5.6mi/14m ). You can get to the city from exit 1 of i80 (1.1mi/3m ); exit 57 of i280ca (3.1mi/7m ); exit 58 of i280ca (2.5mi/6m ). San Francisco, California can reach interstate highways: i80 (1.1mi/3m ); i280ca (3.1mi/7m ); i880ca (8.4mi/15m ). It is also close to local highways: US 101 CA NORTHBOUND SOUTH OF HOPLAND (0.1mi/1m ); US 101 CA SOUTHBOUND SOUTH OF HOPLAND (0.2mi/1m ); 1 LAS CRUCES SAN FRANCISCO (3.1mi/9m ).