Santa Ana, California is close to the interstate highway I-5. It is neighboring other cities: Tustin, CA (2.3mi/5m ); Orange, CA (3.6mi/8m ); Garden Grove, CA (6.3mi/11m ). You can get to the city from exit 104b of i5 (1.8mi/5m ); exit 105a of i5 (6.9mi/10m ); exit 104a of i5 (1.8mi/3m ). Santa Ana, California can reach interstate highways: i5 (1.8mi/5m ); i405ca (6.2mi/11m ); i605ca (17.2mi/22m ). It is also close to local highways: 55 SOUTHBOUND (3.6mi/6m ); 55 NORTHBOUND (3.2mi/6m ); 22 EASTBOUND (3.5mi/7m ).