Cape Girardeau, Missouri is close to the interstate highway I-55. It is neighboring other cities: Gordonville, MO (8.3mi/16m ); Jackson, MO (7.3mi/13m ); Dutchtown, MO (10.4mi/17m ). You can get to the city from exit 96 of i55 (2.4mi/6m ); exit 99 of i55 (5.7mi/10m ); exit 95 of i55 (3.6mi/8m ). Cape Girardeau, Missouri can reach interstate highways: i55 (2.4mi/6m ); i57 (38.1mi/58m ); i24 (48.8mi/1.2h ). It is also close to local highways: MO 34 (3.1mi/6m ); MO 74 (4.3mi/9m ); MO 177 (4.1mi/8m ).