Cairo, Illinois is close to the interstate highway I-57. It is neighboring other cities: Greenfield, MO (6.6mi/14m ); Mound City, IL (5.5mi/9m ); Mounds, IL (6.8mi/12m ). You can get to the city from exit 1 of i57 (14.3mi/19m ); exit 8 of i57 (7.8mi/11m ); exit 12 of i57 (13mi/17m ). Cairo, Illinois can reach interstate highways: i57 (22.2mi/27m ); i55 (40mi/46m ); i24 (37mi/49m ). It is also close to local highways: NHS HIGH PRIORITY CORRIDORS 3 (0.6mi/2m ); IL 3 (1.8mi/4m ); US 51 IL (2.1mi/4m ).