Charleston, Missouri is close to the interstate highway I-57. It is neighboring other cities: Wyatt, MO (6.4mi/11m ); Anniston, MO (10mi/18m ); Bertrand, MO (9.3mi/13m ). You can get to the city from exit 12 of i57 (0.6mi/2m ); exit 10 of i57 (2.8mi/5m ); exit 4 of i57 (18.7mi/22m ). Charleston, Missouri can reach interstate highways: i57 (0.6mi/2m ); i55 (18.2mi/23m ); i24 (45.3mi/1h ). It is also close to local highways: US 60 MO IL (0.4mi/2m ); NHS HIGH PRIORITY CORRIDORS 3 (4.8mi/8m ); MO 77 (0.9mi/3m ).