Sikeston, Missouri is close to the interstate highway I-57. It is neighboring other cities: Morehouse, MO (10.84 ); Bertrand, MO (12.04 ); Blodgett, MO (13.57 ). You can get to the city from exit 69 of i55 (4.46 ); exit 66a of i55 (4.89 ); exit 66b of i55 (4.89 ). Sikeston, Missouri can reach interstate highways: i55 (4.46 ); i57 (4.90 ); i24 (82.84 ). It is also close to local highways: US 61 MO (0.26 ); US 62 MO IL (1.39 ); US 60 MO FROM SPRINGFIELD TO SIKESTON (3.76 ).