Carlisle, Pennsylvania is close to the interstate highway I-81. It is neighboring other cities: Springville, PA (6mi/14m ); Plainfield, PA (4.8mi/9m ); Boiling Springs, PA (6.6mi/15m ). You can get to the city from exit 47 of i81 (3.6mi/8m ); exit 45 of i81 (2.4mi/6m ); exit 48 of i81 (3.2mi/7m ). Carlisle, Pennsylvania can reach interstate highways: i81 (3.6mi/8m ); i76 (26.7mi/40m ); i83 (20.4mi/31m ). It is also close to local highways: PA 34 (0.7mi/3m ); PA 465 (2.6mi/5m ); PA 174 (4.9mi/12m ).