Harrisburg, Pennsylvania is close to the interstate highway I-81. It is neighboring other cities: Lemoyne, PA (2mi/4m ); New Cumberland, PA (2.9mi/6m ); Edgemont, PA (3.1mi/6m ). You can get to the city from exit 43 of i83 (1.8mi/3m ); exit 44a of i83 (1.9mi/4m ); exit 42 of i83 (4.7mi/8m ). Harrisburg, Pennsylvania can reach interstate highways: i83 (1.8mi/3m ); i81 (5.4mi/9m ); i76 (5.5mi/9m ). It is also close to local highways: PA 230 (0.6mi/1m ); US 15 PA (1.8mi/3m ); PA 441 (2.1mi/4m ).