Greenville, South Carolina is close to the interstate highway I-85. It is neighboring other cities: Conestee, SC (4.39 mi ); Greer, SC (4.39 mi ); Taylors, SC (12.35 mi ). You can get to the city from exit 42 of i385sc (2.09 mi ); exit 40b a of i385sc (4.65 mi ); exit 46b a of i85 (6.28 mi ). Greenville, South Carolina can reach interstate highways: i385sc (2.09 mi ); i85 (6.28 mi ); i26 (38.59 mi ). It is also close to local highways: SC 20 (0.24 mi ); SC 124 (0.44 mi ); SC 183 (0.75 mi ).