Port Saint Lucie, Florida is close to the interstate highway I-95. It is neighboring other cities: Jensen Beach, FL (6.6mi/13m ); Stuart, FL (7.4mi/15m ); Palm City, FL (9.6mi/20m ). You can get to the city from exit 121 of i95 (16.2mi/28m ); exit 118 of i95 (10.8mi/19m ); exit 126 of i95 (13.9mi/23m ). Port Saint Lucie, Florida can reach interstate highways: i95 (16.2mi/28m ); i75 (104.5mi/2.1h ); i4 (134.5mi/2.6h ). It is also close to local highways: FL CR ST LUCIE 707 (3.6mi/8m ); FL 732 (3.7mi/8m ); FLORIDA S TURNPIKE (15.8mi/24m ).