Port Saint Lucie, Florida is close to the interstate highway I-95. It is neighboring other cities: Port St. Lucie, FL (0.44 mi ); Jensen Beach, FL (7.96 mi ); Stuart, FL (11.60 mi ). You can get to the city from exit 121 of i95 (11.83 mi ); exit 118 of i95 (12.79 mi ); exit 126 of i95 (14.41 mi ). Port Saint Lucie, Florida can reach interstate highways: i95 (11.83 mi ); i75 (128.47 mi ); i4 (168.59 mi ). It is also close to local highways: FL CR ST LUCIE 707 (4.17 mi ); FL 732 (5.68 mi ); FLORIDA S TURNPIKE (6.41 mi ).