Portsmouth, New Hampshire is close to the interstate highway I-95. It is neighboring other cities: East Candia, NH (0.00 mi ); East Derry, NH (0.00 mi ); North Salem, NH (0.00 mi ). You can get to the city from exit 2 of i95 (13.73 mi ); exit 1 of i95 (16.46 mi ); exit 0 of i95 (17.49 mi ). Portsmouth, New Hampshire can reach interstate highways: i95 (13.73 mi ); i495ma (19.15 mi ); i93 (30.33 mi ). It is also close to local highways: NH 101 (1.45 mi ); US 1 NH (14.89 mi ); MA 150 (15.08 mi ).