Carlisle, South Carolina is close to the interstate highway I-95. It is neighboring other cities: Whitmire, SC (12.5mi/19m ); Union, SC (14.4mi/26m ); Lockhart, SC (22.5mi/41m ). You can get to the city from exit 66 of i26 (30.1mi/46m ); exit 72 of i26 (30.7mi/45m ); exit 60 of i26 (23.6mi/39m ). Carlisle, South Carolina can reach interstate highways: i26 (26mi/47m ); i385sc (28.9mi/38m ); i77 (28.3mi/44m ). It is also close to local highways: SC 121 (1.4mi/5m ); SC 215 (1.4mi/4m ); SC 9 (26.1mi/38m ).