Darlington, South Carolina is close to the interstate highway I-95. It is neighboring other cities: Florence, SC (12.26 mi ); Timmonsville, SC (20.54 mi ); Hartsville, SC (21.74 mi ). You can get to the city from exit 164 of i95 (9.82 mi ); exit 137 of i20 (10.28 mi ); exit 141b a of i20 (11.28 mi ). Darlington, South Carolina can reach interstate highways: i95 (9.82 mi ); i20 (10.28 mi ); i77 (99.47 mi ). It is also close to local highways: SC 340 (0.40 mi ); US 52 SC (0.59 mi ); SC 34 (0.84 mi ).