Effingham, South Carolina is close to the interstate highway I-95. It is neighboring other cities: Florence, SC (6.75 mi ); Coward, SC (9.55 mi ); Scranton, SC (15.82 mi ). You can get to the city from exit 157 of i95 (14.23 mi ); exit 141b a of i20 (15.85 mi ); exit 160a of i95 (15.85 mi ). Effingham, South Carolina can reach interstate highways: i95 (14.23 mi ); i20 (15.85 mi ); i77 (107.33 mi ). It is also close to local highways: US 301 SC (0.34 mi ); SC 327 (0.90 mi ); US 52 SC (1.42 mi ).