Effingham, South Carolina is close to the interstate highway I-95. It is neighboring other cities: Coward, SC (7.7mi/10m ); Florence, SC (9.7mi/12m ); Glendale, SC (13.3mi/18m ). You can get to the city from exit 157 of i95 (12.2mi/21m ); exit 141b a of i20 (12.9mi/18m ); exit 160a of i95 (12.9mi/18m ). Effingham, South Carolina can reach interstate highways: i95 (12.2mi/21m ); i20 (12.9mi/18m ); i77 (80.3mi/1.6h ). It is also close to local highways: US 301 SC (0.8mi/1m ); SC 327 (1.7mi/3m ); US 52 SC (3.3mi/4m ).