Mayesville, South Carolina is close to the interstate highway I-95. It is neighboring other cities: Greenwood, SC (9.6mi/15m ); Elliott, SC (10.1mi/17m ); Sumter, SC (9.8mi/15m ). You can get to the city from exit 135 of i95 (21.9mi/34m ); exit 141 of i95 (17mi/28m ); exit 132 of i95 (35.1mi/44m ). Mayesville, South Carolina can reach interstate highways: i95 (21.9mi/34m ); i20 (22mi/37m ); i77 (58.1mi/1.2h ). It is also close to local highways: SC 154 (0.2mi/0m ); SC 527 (3.1mi/6m ); US 401 SC (6.7mi/14m ).