Santee, South Carolina is close to the interstate highway I-95. It is neighboring other cities: Vance, SC (6.6mi/10m ); Elloree, SC (6.7mi/12m ); Eutawville, SC (12.3mi/21m ). You can get to the city from exit 97 of i95 (4.4mi/7m ); exit 98 of i95 (3.1mi/5m ); exit 93 of i95 (10.1mi/13m ). Santee, South Carolina can reach interstate highways: i95 (4.4mi/7m ); i26 (15.9mi/19m ); i77 (57.1mi/1.1h ). It is also close to local highways: US 15 SC (0.4mi/1m ); US 301 SC (1mi/1m ); SC 267 (1mi/1m ).