Alaska Route 1 is a state highway in the southern portion of the U.S. state of Alaska. It runs from Homer northeast and east to Tok by way of Anchorage. It is the only route in Alaska to contain significant portions of freeway: the Seward Highway in south Anchorage and the Glenn Highway between Anchorage and Palmer.

Route 1 begins at the Alaska Marine Highway's Homer Ferry Terminal at the tip of Homer Spit just south of the end of the Sterling Highway in Homer. It follows the entire Sterling Highway through Soldotna to the junction with the Seward Highway north of Seward, where it meets the north end of Alaska Route 9. There it turns north and follows the Seward Highway to its end in Anchorage, and follows the one-way pairs of Ingra and Gambell Streets and 6th and 5th Avenues, continuing east on 5th Avenue to the beginning of the Glenn Highway. Route 1 follows the entire length of the Glenn Highway, passing the south end of the George Parks Highway (Alaska Route 3) near Wasilla and meeting the Richardson Highway (Alaska Route 4) near Glennallen. A short overlap north along Route 4 takes Route 1 to the Tok Cut-Off Highway, which it follows northeast to its end at the Alaska Highway (Alaska Route 2) at Tok.

The majority of Route 1 is part of the Interstate Highway System; only the route between Homer and Soldotna does not carry an unsigned Interstate designation. The entire length of Interstate A-3 follows Route 1 from the Kenai Spur Highway in Soldotna to the turn in downtown Anchorage; there Interstate A-1 begins, running to Tok along Route 1. (A-1 continues to the Yukon border along Alaska Route 2, the Alaska Highway.) Only a short portion of the Seward Highway south of downtown Anchorage and a longer portion of the Glenn Highway northeast to Route 3 are built to freeway standards; the proposed Highway to Highway Connection would link these through downtown.

All exits are unnumbered.