State Route 107 is a 19-mile (31 km) long route in the western part of the state. The southern terminus of the route is at its junction with State Route 18 approximately three miles northwest of Fayette. The route reaches its northern terminus approximately two miles south of Guin at a junction with State Route 118.

State Route 107 is aligned on a two-lane road as it travels through Fayette and Marion Counties. It is a parallel route to U.S. Highway 43, aligned west of the U.S. Highway. The route serves to connect the towns at its southern and northern termini and does not pass through any incorporated cities or towns.