State Route 168 is a 17.392-mile (27.990 km) long route in the northeastern part of the state. The western terminus of the route is at its junction with State Route 75 at Douglas. The eastern terminus of the route is at its junction with State Route 68 approximately eight miles northeast of Boaz in southwestern DeKalb County.

State Route 168 is aligned along a two-lane road for its duration. From its western origin at Douglas in southeastern Marshall County, the route travels eastwardly as it leads towards Boaz. At Boaz, the route turns northeastwardly, crossing U.S. Highway 431 and leading into DeKalb County. The eastern terminus of the route is at Kilpatrick, an unincorporated community near the border of DeKalb and Marshall Counties.

State Route 168 passes several outlet malls near downtown Boaz. The malls are located west of the junction between US-431 and State Route 168.