Arkansas Highway 164 is a state highway of 61.3 miles (98.7 km) that runs in Johnson and Pope Counties.

The route begins at US 64 near Coal Hill. It runs north across Interstate 40 and AR 352 before turning west. A concurrency begins with AR 103 into Clarksville. The route again meets US 64 before exiting town headed east. AR 164 runs east with AR 123 until Hagarville and continues alone east into Pope County. The route eventually meets AR 7, and the routes concur south to Dover. South of Dover, AR 164 runs southeast to cross AR 124 and terminate at AR 105.

Arkansas Highway 164 Spur is a 0.1-mile (0.16 km)[citation needed] spur route in Clarksville. It is known as Scoggins Street and serves Clarksville Municipal Airport.