Highway 300 (AR 300, Ark. 300 and Hwy. 300) is a designation for two state highway in Central Arkansas. The main route of 29.33 miles (47.20 km) runs from Highway 9/Highway 10 east to Cantrell Road in Little Rock. A second segment runs 1.45 miles (2.33 km) east from Interstate 430 as Colonel Glenn Road.

The route begins at Highway 9/Highway 10 south of Perryville and runs east along the northern edge of the Harris Brake State Wildlife Management Area. Highway 300forms a concurrency south with Highway 216 to Antioch before continuing east to Highway 113. After a brief concurrency south with Highway 113, the route becomes very rural. Highway 300 skirts Lake Maumelle and serves many unincorporated communities such as Little Italy, Monnie Springs, Roland, and Natural Steps before terminating at Cantrell Road.

Highway 300 begins at Interstate 430 and runs east as Colonel Glenn Road. The route runs to Highway 5, which maintains the Colonel Glenn Road designation north and is named Stagecoach Road to the south. Highway 300 had an Average daily traffic (ADT) of 15000 vehicles in 2010 near its eastern terminus.