State Route 286 (SR 286) is a highway in southern Arizona that runs from its junction with State Route 86 west of Tucson to the US-Mexico border at Sasabe. It is largely a north–south route.

The southern terminus of SR 286 is located at the US-Mexico border at Sasabe. The highway heads north from the border traversing a sparsely populated area and does not pass through any cities or towns aside from minor settlements. It provides access to the Buenos Aires National Wildlife Refuge as well as small settlements in Southern Arizona. Although it has a port of entry into Sasabe, Mexico, only dirt roads lead south of this location. The highway generally follows a north-northeast heading for the majority of its route. The northern terminus of the highway is located on SR 86 west of Tucson.

An unpaved road connecting Sasabe to Tucson was built by 1935. The route received a designation as SR 286 in the 1950s. By 1963, a section of the route from SR 86 at the northern terminus to Palo Alto Ranch was paved.

The entire route is in Pima County.