Maryland Route 212, also known as Riggs Road south of MD 193 and Powder Mill Road to its northern end, is a state highway which crosses northern Prince George's County.

Maryland Route 212 guides Riggs Road out of Washington, D.C. along a four-lane divided arterial street, upgraded from the four-lane undivided street it is inside the capital district. MD 212 continues north, widening to six lanes as it passes through Chillum, with several homes and businesses directly accessing the route. After crossing Sligo Creek, the route intersects MD 410 (East–West Highway). After passing under a transmission line, the route intersects MD 193 (University Boulevard) and narrows to a two-lane street. Exiting the much denser suburban area only momentarily, the route bridges the Northwest Branch and the Northwest Branch Trail, and eventually the route passes through Adelphi. After passing over the Capital Beltway, the route intersects Powder Mill Road as it passes close to the Montgomery County line.

MD 212 then takes on the name of Powder Mill Road and continues to the northeast, passing by a US Army research center. Entering suburbia again, the route dualizes to interchange with Interstate 95. At the very last ramp of I-95, the MD 212 designation ends.

Powder Mill Road continues east of here as MD 212A, passing through more suburbia and narrowing to a two-lane road once more. The route intersects Rhode Island Avenue as it continues to US 1. After meeting the U.S. route, it continues east to eventually end at MD 201 (Edmonston Avenue).

The entire route is in Prince George's County.

The entire route is in Beltsville, Prince George's County.