State Route 122 (SR-122) is a three-mile (5 km) long route in Coffee County in the southern part of the state. The western terminus of the route is at its junction with U.S. Highway 84 at New Brockton. The eastern terminus of the route is at its junction with State Route 51 north of Enterprise.

SR-122 begins at an intersection with US-84/SR-12 in New Brockton, heading northwest on two-lane undivided McKinnon Street. The road heads through rural areas of development before passing homes. In the center of New Brockton, the route turns northeast onto North John Street and continues past more residences. Upon leaving New Brockton, SR-122 heads into a mix of farmland and woodland as an unnamed road. The route turns more to the east as it comes to its eastern terminus at SR-51.

The entire route is in Coffee County.