State Route 54 (SR 54) is a state highway that runs southwest-to-northeast through portions of Troup, Meriwether, Coweta, Fayette, Clayton, and Fulton counties in western Georgia. The route runs from its southwestern terminus at US 27 and SR 1 west of Hogansville to its northeastern terminus at I-75/I-85/SR 401/SR 403 in southwestern Atlanta.

The route initially runs east from its southwestern terminus through Hogansville in Troup County, crosses I-85 at the county line with Meriwether County, and continues northeast through Lone Oak and Luthersville. The route crosses into Coweta County and through Sharpsburg on through Peachtree City and Fayetteville in Fayette County.

Continuing to run in a northeasterly direction into Jonesboro in Clayton, the route then turns north, crosses I-75 and Morrow, then continues through Forest Park, crosses I-285 east of Hartsfield–Jackson Atlanta International Airport, and runs to its northeastern terminus at the Downtown Connector in Atlanta

The southern end of State Route 54 from U.S. Route 27 to Hogansville was previously numbered State Route 258 until 1963-1964.

State Route 54 Spur also known as Park Street, is a route to be measured in feet that eases the transition for a traveler going west on State Route 54 wishing to go south on State Route 41 or a traveler going north on State Route 41 wishing to go east on State Route 54. The southern terminus meets as a Y-type intersection with State Route 41 and its northern terminus meets State Route 54 Westbound to its left, State Route 54 Eastbound straight ahead, and a county road to its right.